Curcumin Qhia los txhim kho cov kab mob o ntawm cov hlab ntsha

Cov txiaj ntsig ntawm kev tshawb fawb tshiab luam tawm nyob rau hauv phau ntawv Journal Biomed Central BMC qhia tias turmeric extract tau zoo li paracetamol hauv kev txo qhov mob thiab lwm yam tsos mob ntawm lub hauv caug osteoarthritis (OA).Txoj kev tshawb no qhia tau hais tias bioavailable compound tau zoo dua los txo qhov mob.

Osteoarthritis yog ib qho kab mob degenerative ntawm cov pob qij txha uas ua los ntawm kev tawg ntawm pob txha mos, pob qij txha, ligaments, thiab cov pob txha hauv qab.Feem ntau tshwm sim ntawm osteoarthritis yog txhav thiab mob.

Thawj coj los ntawm Shuba Singhal, PhD, qhov kev tshawb fawb soj ntsuam no tau ua tiav ntawm Lub Tsev Haujlwm Saib Xyuas Kev Kho Mob ntawm Lok Nayak Jai Prakash Tsev Kho Mob / Maulana Azad Medical College, New Delhi.Rau txoj kev tshawb no, 193 tus neeg mob tau kuaj pom tias muaj osteoarthritis ntawm lub hauv caug tau randomized kom tau txais turmeric extract (BCM-95) li 500 mg capsule ob zaug ib hnub twg, lossis 650 mg ntsiav tshuaj ntawm paracetamol peb zaug ib hnub rau rau lub lis piam.

Lub hauv caug mob caj dab cov tsos mob ntawm qhov mob, sib koom ua ke, thiab lub cev tsis muaj zog tau soj ntsuam siv Western Ontario thiab McMaster Universities Osteoarthritis Index (WOMAC).Tom qab 6 lub lis piam ntawm kev kho mob, kev soj ntsuam cov lus teb tau pom tias muaj kev txhim kho tseem ceeb hauv WOMAC cov qhab nia thoob plaws txhua qhov kev ntsuas piv rau pawg paracetamol, nrog 18% ntawm pawg BCM-95 qhia txog 50% kev txhim kho, thiab 3% ntawm cov neeg kawm sau tseg 70% kev txhim kho.

Cov txiaj ntsig no tau pom zoo nyob rau hauv BCM-95 pawg cov kab mob ntshav qab zib: CRP qib tau txo qis los ntawm 37.21%, thiab TNF-α qib tau txiav los ntawm 74.81%, qhia tias BCM-95 ua tau zoo dua li paracetamol.

Txoj kev tshawb no yog ua raws li txoj kev tshawb fawb Arjuna tau ua dhau ib xyoos dhau los uas pom tau tias muaj kev sib txuas zoo ntawm nws cov qauv curcumin flagship thiab kev saib xyuas osteoarthritic.

"Lub hom phiaj ntawm txoj kev tshawb fawb tam sim no yog tsim los ntawm cov kev tshawb fawb yav dhau los los muab qhov pom tseeb zoo dua thiab qhov tshwj xeeb los ntawm kev suav nrog ntau cov cim thiab cov txheej txheem qhab nia zoo dua," said Benny Antony, tus thawj coj koom tes ntawm Arjuna."Kev tiv thaiv kev mob caj dab ntawm BCM-95 hauv osteoarthritis yog vim nws lub peev xwm los hloov kho cov cim tiv thaiv TNF thiab CRP."

Lub hauv caug OA yog qhov ua rau muaj kev tsis taus thiab mob ntawm cov neeg laus thiab cov hnub nyoog laus.Kwv yees li ntawm 10 mus rau 15% ntawm tag nrho cov neeg laus dua 60 xyoo muaj qee qhov OA, nrog rau cov poj niam ntau dua li txiv neej.

Nipen Lavingia, tus kws tshaj lij kev lag luam tshiab rau Arjuna Natural nyob hauv Dallas, TX tau hais tias "Qhov kev tshawb fawb no rov lees paub txog kev tiv thaiv kev mob caj dab ntawm BCM-95 thiab muab kev cia siab tshiab rau ntau lab tus neeg los txhim kho lawv lub neej zoo,"

"Peb tab tom kawm ntxiv txog cov txheej txheem tom qab curcumin cov tshuaj tiv thaiv kab mob uas peb ntseeg tias yog qhov tshwm sim ntawm nws lub peev xwm los tiv thaiv cov teeb meem tsis zoo, xws li prostaglandins, leukotrienes, thiab cyclooxygenase-2.Tsis tas li ntawd, curcumin tau pom tias yuav txwv ntau cov cytokines pro-inflammatory thiab cov neeg nruab nrab ntawm lawv tso tawm, xws li qog necrosis factor-α (TNF-α), IL-1, IL-8, thiab nitric oxide synthase, "said Antony.

BCM-95 qhov tshwj xeeb fusion ntawm curcuminoids thiab turmerone-nplua nuj tseem ceeb roj Cheebtsam kov yeej curcumin tus yam ntxwv bioavailability hurdles vim nws qhov siab lipophilic xwm.